ヒストンデアセチラーゼ6治療薬市場:パイプラインレビュー(2019年下半期)

◆英語タイトル:Histone Deacetylase 6 - Pipeline Review, H2 2019
◆商品コード:GDATA20MY0370
◆発行会社(リサーチ会社):Global Markets Direct
◆発行日:2019年12月27日
◆ページ数:141
◆レポート言語:英語
◆レポート形式:PDF
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【レポートの概要】

Histone Deacetylase 6 – Pipeline Review, H2 2019
Summary

Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) pipeline Target constitutes close to 49 molecules. Out of which approximately 40 molecules are developed by companies and remaining by the universities/institutes. The latest report Histone Deacetylase 6 – Pipeline Review, H2 2019, outlays comprehensive information on the Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.

Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) – Histone deacetylase 6 is an enzyme encoded by the HDAC6 gene. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. It is involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. It plays a key role in the degradation of misfolded proteins. It acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy. The molecules developed by companies in Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 5, 4, 1, 22 and 8 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 7 and 2 molecules, respectively. Report covers products from therapy areas Oncology, Central Nervous System, Genetic Disorders, Immunology, Toxicology, Gastrointestinal, Infectious Disease, Musculoskeletal Disorders and Undisclosed which include indications Multiple Myeloma (Kahler Disease), Alzheimer’s Disease, Melanoma, Solid Tumor, Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Charcot-Marie-Tooth Disease, Charcot-Marie-Tooth Disease Type II, Glioblastoma Multiforme (GBM), Multiple Sclerosis, Non-Small Cell Lung Cancer, Pancreatic Cancer, Refractory Multiple Myeloma, Relapsed Multiple Myeloma, Triple-Negative Breast Cancer (TNBC), Chemotherapy Induced Peripheral Neuropathy, Chronic Lymphocytic Leukemia (CLL), Colorectal Cancer, Depression, Diffuse Large B-Cell Lymphoma, Follicular Lymphoma, Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma), Leukemia, Mantle Cell Lymphoma, Ovarian Cancer, Rheumatoid Arthritis, Squamous Cell Carcinoma, Systemic Lupus Erythematosus, Amyotrophic Lateral Sclerosis, Autoimmune Disorders, B-Cell Non-Hodgkin Lymphoma, Basal Cell Carcinoma (Basal Cell Epithelioma), Bile Duct Cancer (Cholangiocarcinoma), Blood Cancer, Breast Cancer, Burkitt Lymphoma, Cervical Cancer, CNS Lymphoma, Colon Cancer, Crohn’s Disease (Regional Enteritis), Cutaneous T-Cell Lymphoma, Diabetic Neuropathic Pain, Endometrial Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Fibrosis, Gallbladder Cancer, Gastric Cancer, Gliosarcoma, High-Grade Glioma, Human Papillomavirus (HPV) Associated Cancer, Huntington Disease, Lung Adenocarcinoma, Lupus Nephritis, Lymphoma, Marginal Zone B-cell Lymphoma, Metastatic Biliary Tract Cancer, Metastatic Breast Cancer, Mycosis Fungoides, Myelodysplastic Syndrome, Neuroblastoma, Neurology, Neuropathic Pain (Neuralgia), Non-Hodgkin Lymphoma, NUT Midline Carcinoma (NMC or Nuclear Protein in Testis Midline Carcinoma), Parkinson’s Disease, Pediatric Diffuse Intrinsic Pontine Glioma, Peritoneal Cancer, Polycystic Kidney Disease, Rectal Cancer, Recurrent Medulloblastoma, Rett Syndrome, Sepsis, Tauopathies, Ulcerative Colitis and Unspecified.

Furthermore, this report also reviews key players involved in Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Scope

- The report provides a snapshot of the global therapeutic landscape for Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98)
- The report reviews Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) targeted therapeutics and enlists all their major and minor projects
- The report assesses Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) targeted therapeutics

Reasons to buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

【レポートの目次】

Table of Contents
List of Tables
List of Figures
Introduction
Global Markets Direct Report Coverage
Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) – Overview
Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) – Therapeutics Development
Products under Development by Stage of Development
Products under Development by Therapy Area
Products under Development by Indication
Products under Development by Companies
Products under Development by Universities/Institutes
Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) – Therapeutics Assessment
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) – Companies Involved in Therapeutics Development
ATP Biopharm
Augustine Therapeutics
Bristol-Myers Squibb Co
Chong Kun Dang Pharmaceutical Corp
CStone Pharmaceuticals Co Ltd
Curis Inc
Eikonizo Therapeutics Inc
Guangdong Zhongsheng Pharmaceutical Co Ltd
Hillstream BioPharma Inc
HitGen LTD
Jubilant Biosys Ltd
Kancera AB
Karus Therapeutics Ltd
Konruns Pharmaceutical Co Ltd
Medivir AB
Merck & Co Inc
OnKure Inc
Quimatryx SL
Selenity Therapeutics Inc
Shuttle Pharmaceuticals Inc
SignalRx Pharmaceuticals Inc
SK Biopharmaceuticals Co Ltd
Starwise Therapeutics LLC
Histone Deacetylase 6 (Protein Phosphatase 1 Regulatory Subunit 90 or HDAC6 or EC 3.5.1.98) – Drug Profiles
ACY-1083 – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
ACY-738 – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
ACY-775 – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
ADV-300 – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Featured News & Press Releases
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer

List of Tables
Number of Products under Development by Stage of Development, H2 2019
Number of Products under Development by Therapy Areas, H2 2019
Number of Products under Development by Indications, H2 2019
Number of Products under Development by Indications, H2 2019 (Contd..1), H2 2019
Number of Products under Development by Indications, H2 2019 (Contd..2), H2 2019
Number of Products under Development by Indications, H2 2019 (Contd..3), H2 2019
Number of Products under Development by Companies, H2 2019
Number of Products under Development by Companies, H2 2019 (Contd..1)
Products under Development by Companies, H2 2019
Products under Development by Companies, H2 2019 (Contd..1), H2 2019
Products under Development by Companies, H2 2019 (Contd..2), H2 2019
Products under Development by Companies, H2 2019 (Contd..3), H2 2019
Products under Development by Companies, H2 2019 (Contd..4), H2 2019
Products under Development by Companies, H2 2019 (Contd..5), H2 2019
Products under Development by Companies, H2 2019 (Contd..6), H2 2019
Number of Products under Investigation by Universities/Institutes, H2 2019
Products under Investigation by Universities/Institutes, H2 2019
Number of Products by Stage and Mechanism of Actions, H2 2019
Number of Products by Stage and Route of Administration, H2 2019
Number of Products by Stage and Molecule Type, H2 2019
Pipeline by ATP Biopharm, H2 2019
Pipeline by Augustine Therapeutics, H2 2019
Pipeline by Bristol-Myers Squibb Co, H2 2019
Pipeline by Chong Kun Dang Pharmaceutical Corp, H2 2019
Pipeline by CStone Pharmaceuticals Co Ltd, H2 2019
Pipeline by Curis Inc, H2 2019
Pipeline by Eikonizo Therapeutics Inc, H2 2019
Pipeline by Guangdong Zhongsheng Pharmaceutical Co Ltd, H2 2019
Pipeline by Hillstream BioPharma Inc, H2 2019
Pipeline by HitGen LTD, H2 2019
Pipeline by Jubilant Biosys Ltd, H2 2019
Pipeline by Kancera AB, H2 2019
Pipeline by Karus Therapeutics Ltd, H2 2019
Pipeline by Konruns Pharmaceutical Co Ltd, H2 2019
Pipeline by Medivir AB, H2 2019
Pipeline by Merck & Co Inc, H2 2019
Pipeline by OnKure Inc, H2 2019
Pipeline by Quimatryx SL, H2 2019
Pipeline by Selenity Therapeutics Inc, H2 2019
Pipeline by Shuttle Pharmaceuticals Inc, H2 2019
Pipeline by SignalRx Pharmaceuticals Inc, H2 2019
Pipeline by SK Biopharmaceuticals Co Ltd, H2 2019
Pipeline by Starwise Therapeutics LLC, H2 2019
Dormant Products, H2 2019
Dormant Products, H2 2019 (Contd..1), H2 2019
Dormant Products, H2 2019 (Contd..2), H2 2019
Dormant Products, H2 2019 (Contd..3), H2 2019
Dormant Products, H2 2019 (Contd..4), H2 2019

【掲載企業】

ATP Biopharm
Augustine Therapeutics
Bristol-Myers Squibb Co
Chong Kun Dang Pharmaceutical Corp
CStone Pharmaceuticals Co Ltd
Curis Inc
Eikonizo Therapeutics Inc
Guangdong Zhongsheng Pharmaceutical Co Ltd
Hillstream BioPharma Inc
HitGen LTD
Jubilant Biosys Ltd
Kancera AB
Karus Therapeutics Ltd
Konruns Pharmaceutical Co Ltd
Medivir AB
Merck & Co Inc
OnKure Inc
Quimatryx SL
Selenity Therapeutics Inc
Shuttle Pharmaceuticals Inc
SignalRx Pharmaceuticals Inc
SK Biopharmaceuticals Co Ltd
Starwise Therapeutics LLC

【免責事項】
https://www.marketreport.jp/reports-disclaimer

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