グリコーゲン合成酵素キナーゼ3ベータ治療薬市場:パイプラインレビュー(2019年下半期)

◆英語タイトル:Glycogen Synthase Kinase 3 Beta - Pipeline Review, H2 2019
◆商品コード:GDATA20MY0416
◆発行会社(リサーチ会社):Global Markets Direct
◆発行日:2019年12月27日
◆ページ数:69
◆レポート言語:英語
◆レポート形式:PDF
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【レポートの概要】

Glycogen Synthase Kinase 3 Beta – Pipeline Review, H2 2019
Summary

According to the recently published report ‘Glycogen Synthase Kinase 3 Beta – Pipeline Review, H2 2019′; Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) pipeline Target constitutes close to 19 molecules. Out of which approximately 14 molecules are developed by companies and remaining by the universities/institutes.

Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) – Glycogen synthase kinase 3 beta also known as GSK3B is an enzyme encoded by the GSK3B. It constitutively activate protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules. It mediates the development of insulin resistance by regulating activation of transcription factors. It regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. It plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. It regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2.

The report ‘Glycogen Synthase Kinase 3 Beta – Pipeline Review, H2 2019′ outlays comprehensive information on the Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.

It also reviews key players involved in Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase II, Preclinical and Discovery stages are 2, 8 and 4 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 3 and 2 molecules, respectively. Report covers products from therapy areas Central Nervous System, Oncology, Musculoskeletal Disorders, Genetic Disorders, Ophthalmology and Undisclosed which include indications Alzheimer’s Disease, Pancreatic Cancer, Lung Cancer, Amyotrophic Lateral Sclerosis, Bladder Cancer, Bone Fracture, Breast Cancer, Cognitive Impairment, Glioblastoma Multiforme (GBM), Kidney Cancer (Renal Cell Cancer), Liver Cancer, Lymphoma, Menkes Disease (Kinky Hair Disease), Metastatic Lung Cancer, Multiple Sclerosis, Myotonic Dystrophy, Neuroblastoma, Ovarian Cancer, Pervasive Developmental Disorder (PDD), Retinitis Pigmentosa (Retinitis), Sarcomas, Tauopathies and Unspecified.

Scope

- The report provides a snapshot of the global therapeutic landscape for Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1)
- The report reviews Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) targeted therapeutics and enlists all their major and minor projects
- The report assesses Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) targeted therapeutics

Reasons to buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

【レポートの目次】

Table of Contents
List of Tables
List of Figures
Introduction
Global Markets Direct Report Coverage
Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) – Overview
Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) – Therapeutics Development
Products under Development by Stage of Development
Products under Development by Therapy Area
Products under Development by Indication
Products under Development by Companies
Products under Development by Universities/Institutes
Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) – Therapeutics Assessment
Assessment by Mechanism of Action
Assessment by Route of Administration
Assessment by Molecule Type
Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) – Companies Involved in Therapeutics Development
Actuate Therapeutics Inc
Alzamend Neuro Inc
AMO Pharma Ltd
Angelini Group
Ankar Pharma SL
Avenzoar Pharmaceuticals Inc
CerebraMed
Collaborative Medicinal Development LLC
InnoBioscience LLC
MAIA Biotechnology Inc
Novosteo Inc
Park Active Molecules
Zovis Pharmaceuticals
Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) – Drug Profiles
9-ING41 – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
AP-001 – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
AP-1 – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Drug to Inhibit GSK3-Beta for Alzheimer’s Disease – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Drugs for Unspecified Indication – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
IB-AD – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
lithium salicylate – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
manzamine A – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
MBT-826 – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
PAM-14 – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecule to Inhibit GSK-3 Beta for Menkes Disease and Tauopathies – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecule to Inhibit GSK3B for Ovarian Cancer – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit BACE-1 and GSK-3 Beta for Alzheimer’s Disease – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit GSK-3 Beta for CNS Disorders – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Inhibit GSK3B for Amyotropic Lateral Sclerosis – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Small Molecules to Target GSK3B and Nrf2 for Alzheimer’s Disease – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Synthetic Peptide to Inhibit GSK3B for Bone Fracture – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Synthetic Peptides to Inhibit GSK3B for Cardiovascular, Central Nervous System and Metabolic Disorders – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
tideglusib – Drug Profile
Product Description
Mechanism Of Action
R&D Progress
Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) – Dormant Products
Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) – Discontinued Products
Glycogen Synthase Kinase 3 Beta (Serine/Threonine Protein Kinase GSK3B or GSK3B or EC 2.7.11.26 or EC 2.7.11.1) – Product Development Milestones
Featured News & Press Releases
Sep 16, 2019: AMO Pharma participates in Workshop on central nervous system involvement in progression and treatment of Myotonic Dystrophy during Myotonic Dystrophy Foundation Annual Conference
Jun 13, 2019: Updates on development of AMO Pharma’s AMO-02 presented at International Myotonic Dystrophy Consortium Meeting
May 06, 2019: AMO Pharma presents statistical analysis of results of phase 2 study of AMO-02 in adolescents with autism spectrum disorder
Dec 17, 2018: Actuate Therapeutics opens phase 1/2 clinical study of 9-ING-41 in patients with refractory cancers
Oct 30, 2018: AMO Pharma reports positive results from AMO-02 trial
Oct 23, 2018: AMO Therapeutics announces presentation of concordant analysis of results of phase 2 study of AMO-02 in treatment of myotonic dystrophy
Mar 15, 2018: AMO Pharma Announces Results of Phase 2 Proof-of-Concept Study of AMO-02 in Congenital and Childhood Onset Myotonic Dystrophy Type 1
Feb 15, 2018: Actuate Therapeutics Announces FDA Acceptance Of IND Application For 9-ING-41 And Clearance To Proceed With Clinical Study In Patients With Advanced Cancers
Oct 26, 2017: Actuate Therapeutics Receives Rare Pediatric Disease Designation for 9-ING-41 for Treatment of Neuroblastoma
Oct 18, 2017: AMO Pharma Presents Positive Interim Analysis of Data from Congenital Myotonic Dystrophy Study at American Neurological Association Annual Meeting
Sep 25, 2017: AMO Pharma Reports Update on Positive Interim Analysis for the First Cohort of Phase IIa Congenital Myotonic Dystrophy Study
Jul 27, 2017: AMO Pharma Receives FDA Orphan Drug Designation for AMO-02 for Treatment of Congenital Myotonic Dystrophy
May 30, 2017: AMO Pharma Announces FDA Fast Track Designation For AMO-02 For Treatment Of Congenital Myotonic Dystrophy
Apr 03, 2017: Actuate Therapeutics’ Programs Highlighted in Clinical Cancer Research
Aug 10, 2016: AMO Pharma Initiates Phase 2 Clinical Trial in UK for AMO-02 for Treatment of Congenital and Juvenile Onset Myotonic Dystrophy
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer

List of Tables
Number of Products under Development by Stage of Development, H2 2019
Number of Products under Development by Therapy Areas, H2 2019
Number of Products under Development by Indications, H2 2019
Number of Products under Development by Indications, H2 2019 (Contd..1), H2 2019
Number of Products under Development by Companies, H2 2019
Products under Development by Companies, H2 2019
Products under Development by Companies, H2 2019 (Contd..1), H2 2019
Number of Products under Investigation by Universities/Institutes, H2 2019
Products under Investigation by Universities/Institutes, H2 2019
Number of Products by Stage and Mechanism of Actions, H2 2019
Number of Products by Stage and Route of Administration, H2 2019
Number of Products by Stage and Molecule Type, H2 2019
Pipeline by Actuate Therapeutics Inc, H2 2019
Pipeline by Alzamend Neuro Inc, H2 2019
Pipeline by AMO Pharma Ltd, H2 2019
Pipeline by Angelini Group, H2 2019
Pipeline by Ankar Pharma SL, H2 2019
Pipeline by Avenzoar Pharmaceuticals Inc, H2 2019
Pipeline by CerebraMed, H2 2019
Pipeline by Collaborative Medicinal Development LLC, H2 2019
Pipeline by InnoBioscience LLC, H2 2019
Pipeline by MAIA Biotechnology Inc, H2 2019
Pipeline by Novosteo Inc, H2 2019
Pipeline by Park Active Molecules, H2 2019
Pipeline by Zovis Pharmaceuticals, H2 2019
Dormant Products, H2 2019
Dormant Products, H2 2019 (Contd..1), H2 2019
Dormant Products, H2 2019 (Contd..2), H2 2019
Discontinued Products, H2 2019

【掲載企業】

Actuate Therapeutics Inc
Alzamend Neuro Inc
AMO Pharma Ltd
Angelini Group
Ankar Pharma SL
Avenzoar Pharmaceuticals Inc
CerebraMed
Collaborative Medicinal Development LLC
InnoBioscience LLC
MAIA Biotechnology Inc
Novosteo Inc
Park Active Molecules
Zovis Pharmaceuticals

【免責事項】
https://www.marketreport.jp/reports-disclaimer

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