※関連の医療情報レポート

1. サイクリン依存性キナーゼ2治療薬市場：パイプラインレビュー（2019年下半期）
   GDATA20MY0340 / Global Markets Direct / 2019年12月27日 / ...Cyclin Dependent Kinase 2 - Pipeline Review, H2 2019 Summary Cyclin Dependent Kinase 2 (p33 Protein Kinase or Cell Division Protein Kinase 2 or CDK2 or EC 2.7.11.22) pipeline Target constitutes close to 16 molecules. Out of which approximately 13 molecules are developed by companies and remaining by the universities/institutes. The latest report Cyclin Dependent Kinase 2 - Pipeline Review, H2 2019, outlays comprehensive information on the Cyclin Dependent Kinase 2 (p33 Protein Kinase or Cell Division Protein Kinase 2 or CDK2 or EC 2.7.11.22) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route...
2. サイクリン依存性キナーゼ7治療薬市場：パイプラインレビュー（2019年下半期）
   GDATA20MY0345 / Global Markets Direct / 2019年12月27日 / ...Cyclin Dependent Kinase 7 - Pipeline Review, H2 2019 Summary Cyclin Dependent Kinase 7 (39 kDa Protein Kinase or CDK Activating Kinase 1 or Cell Division Protein Kinase 7 or TFIIH Basal Transcription Factor Complex Kinase Subunit or Serine/Threonine Protein Kinase 1 or CDK7 or EC 2.7.11.22 or EC 2.7.11.23) - Cell division protein kinase 7 is an enzyme that in humans is encoded by the CDK7 gene. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. It phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and...
3. サイクリン依存性キナーゼ9治療薬市場：パイプラインレビュー（2019年下半期）
   GDATA20MY0446 / Global Markets Direct / 2019年12月27日 / ...Cyclin Dependent Kinase 9 - Pipeline Review, H2 2019 Summary Cyclin Dependent Kinase 9 (Tat Associated Kinase Complex Catalytic Subunit or C 2K or Cell Division Cycle 2 Like Protein Kinase 4 or Cell Division Protein Kinase 9 or Serine/Threonine Protein Kinase PITALR or CDK9 or EC 2.7.11.22 or EC 2.7.11.23) - Cyclin-dependent kinase 9 (CDK9) is a cyclin-dependent kinase associated with P-TEFb. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase...
4. 細胞分裂周期7相同体タンパク質キナーゼ治療薬市場：パイプラインレビュー（2019年下半期）
   GDATA20MY0429 / Global Markets Direct / 2019年12月27日 / ...Cell Division Cycle 7 Related Protein Kinase - Pipeline Review, H2 2019 Summary Cell Division Cycle 7 Related Protein Kinase (CDC7 or EC 2.7.11.1) - Cell division cycle 7-related protein kinase is an enzyme encoded by the CDC7 gene. It phosphorylate substrates that regulate the G1/S phase transition and DNA replication. Overexpression of CDC7 is associated with neoplastic transformation for some tumors. Cell Division Cycle 7 Related Protein Kinase (CDC7 or EC 2.7.11.1) pipeline Target constitutes close to 8 molecules. Out of which approximately 6 molecules are developed by companies and remaining by the universities/institutes. The molecules developed by companies...
5. サイクリン依存性キナーゼ6治療薬市場：パイプラインレビュー（2019年下半期）
   GDATA20MY0439 / Global Markets Direct / 2019年12月27日 / ...Cyclin Dependent Kinase 6 - Pipeline Review, H2 2019 Summary Cyclin Dependent Kinase 6 (Cell Division Protein Kinase 6 or Serine/Threonine Protein Kinase PLSTIRE or CDK6 or EC 2.7.11.22) - Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene. It is involved in initiation and maintenance of cell cycle exit during cell differentiation, prevents cell proliferation and regulates negatively cell differentiation. It is required during thymocyte development. It promotes the production of newborn neurons, probably by modulating G1 length, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation....
6. サイクリン依存性キナーゼ4治療薬市場：パイプラインレビュー（2019年下半期）
   GDATA20MY0308 / Global Markets Direct / 2019年12月27日 / ...Cyclin Dependent Kinase 4 - Pipeline Review, H2 2019 Summary Cyclin Dependent Kinase 4 (Cell Division Protein Kinase 4 or PSK J3 or CDK4 or EC 2.7.11.22) - Cyclin-dependent kinase 4 is an enzyme encoded by the CDK4 gene. Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Activation of the cyclin-D-CDK4 complex appears to require other factors such as recruitment of the substrate via a substrate recruitment motif, and/or formation of the CDKN1B ternary complex. Cyclin Dependent Kinase 4 (Cell Division Protein...
7. セリントレオニンプロテインキナーゼATR治療薬市場：パイプラインレビュー（2019年下半期）
   GDATA20MY0452 / Global Markets Direct / 2019年12月27日 / ...SerineThreonine Protein Kinase ATR - Pipeline Review, H2 2019 Summary According to the recently published report 'SerineThreonine Protein Kinase ATR - Pipeline Review, H2 2019'; Serine/Threonine Protein Kinase ATR (Ataxia Telangiectasia And Rad3 Related Protein or FRAP Related Protein 1 or ATR or EC 2.7.11.1) pipeline Target constitutes close to 17 molecules. Out of which approximately 16 molecules are developed by companies and remaining by the universities/institutes. Serine/Threonine Protein Kinase ATR (Ataxia Telangiectasia And Rad3 Related Protein or FRAP Related Protein 1 or ATR or EC 2.7.11.1) - Serine/threonine-protein kinase ATR is an enzyme encoded by the ATR gene. It...
8. 受容体チロシンプロテインキナーゼERBB4治療薬市場：パイプラインレビュー（2019年下半期）
   GDATA20MY0334 / Global Markets Direct / 2019年12月27日 / ...Receptor Tyrosine Protein Kinase ERBB 4 - Pipeline Review, H2 2019 Summary According to the recently published report 'Receptor Tyrosine Protein Kinase ERBB 4 - Pipeline Review, H2 2019'; Receptor Tyrosine Protein Kinase ERBB 4 (Tyrosine Kinase Type Cell Surface Receptor HER4 or Proto Oncogene Like Protein c ErbB 4 or p180erbB4 or HER4 or ERBB4 or EC 2.7.10.1) pipeline Target constitutes close to 17 molecules. Out of which approximately 16 molecules are developed by companies and remaining by the universities/institutes. Receptor Tyrosine Protein Kinase ERBB 4 (Tyrosine Kinase Type Cell Surface Receptor HER4 or Proto Oncogene Like Protein c...
9. チロシンプロテインキナーゼ受容体TYRO3治療薬市場：パイプラインレビュー（2019年下半期）
   GDATA20MY0136 / Global Markets Direct / 2019年11月25日 / ...Tyrosine Protein Kinase Receptor TYRO3 - Pipeline Review, H2 2019 Summary Tyrosine Protein Kinase Receptor TYRO3 (Tyrosine Protein Kinase BYK or Tyrosine Protein Kinase DTK or Tyrosine Protein Kinase RSE or Tyrosine Protein Kinase TIF or Tyrosine Protein Kinase SKY or TYRO3 or EC 2.7.10.1) - Tyrosine-protein kinase receptor TYRO3 is an enzyme encoded by the TYRO3 gene. TYRO3 activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays an important role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, cytoskeleton reorganization, inhibition of Toll-like receptors...
10. チロシンプロテインキナーゼITKTSK治療薬市場：パイプラインレビュー（2019年下半期）
    GDATA20MY0341 / Global Markets Direct / 2019年12月27日 / ...Tyrosine Protein Kinase ITKTSK - Pipeline Review, H2 2019 Summary Tyrosine Protein Kinase ITK/TSK (Interleukin 2 Inducible T Cell Kinase or T Cell Specific Kinase or Kinase EMT or Tyrosine Protein Kinase Lyk or ITK or EC 2.7.10.2) - Tyrosine-protein kinase ITK/TSK or interleukin-2-inducible T-cell kinase or simply ITK is a protein encoded by the ITK gene. It plays an essential role in regulation of the adaptive immune response. When antigen presenting cells (APC) activate T-cell receptor (TCR) a series of phosphorylation lead to the recruitment of ITK to the cell membrane, stimulate TCR receptor, where it is phosphorylated by...